Patients describe the debilitating symptoms they feel between and during attacks.


[Text on screen]
The following video represents the experiences of some individuals with acute hepatic porphyria (AHP). These disease manifestations may not be reflective of other individuals' presentations of AHP.

[Text on screen]
“Describing a porphyria attack as painful is an understatement—torture comes closer,” says Desiree, patient and co-founder of the American Porphyria Foundation.

[Link on screen]

Ania:Pain is the biggest thing, the biggest symptom, and its abdominal pain. It was crippling. By crippling I mean it's like someone is holding, squeezing, stabbing. You're not able to function. You can't do anything; you just, you just want to die. It is that bad. [Lower third on screen to read: Ania living with acute intermittent porphyria (AIP)]

 Mary:You can have 10 different pains in 10 different distinct parts of your body at the same time. And all of them are different but screaming out-of-control pain. Sometimes it feels like you're being clawed at the same time as being stabbed with hot pokers. [Lower third on screen to read: Mary living with acute intermittent porphyria (AIP)]

 Colin:One thing you really have to understand about porphyria is that the pain that it causes is so severe that you are willing to go to any extreme to just make it stop. I mean just for 15 seconds, 30 seconds. You know, just please just make it go away for... just a minute. Let me catch my breath. [Lower third on screen to read: Colin living with porphyria]

 Nathan:When I think about the pain it's very excruciating. I don't know what it feels like to have a baby, but I know what it feels like to scream and cry in the emergency room. And to be a grown man in the emergency room screaming and crying... It is, it's just something that I wouldn't want anyone to go through. [Lower third on screen to read: Nathan living with heredity coproporphyria (HCP)]

[Text on screen]
Greater than 90% of people with acute hepatic porphyria (AHP) attacks experience severe abdominal pain.

 [Text on screen]
To learn more about AHP, visit Alnylam’s

 [PinpointAHP logo and Alnylam logo]

 © 2020 Alnylam Pharmaceuticals, Inc. All rights reserved. AS1-USA-00452


SIGN UP to receive updated information about AHP from Alnylam.

All fields are required


Thank you for connecting with us.

One step away! You will receive an email shortly to verify your information and complete enrollment for AHP updates for Alnylam.